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Frequently Asked Questions

What are exosomes, and why does their source matter?

Exosomes are tiny vesicles (30-150 nm) released by cells that carry proteins, lipids, and RNA to influence other cells’ behavior. Their source matters because the parent cell type determines their cargo and therapeutic potential. Exosomes from Wharton’s jelly, a gel-like tissue in the umbilical cord, come from mesenchymal stem cells (MSCs) and are packed with regenerative molecules tailored for healing and growth.

What is Wharton’s jelly, and why is it used for exosomes?

Wharton’s jelly is the connective tissue surrounding the umbilical cord’s blood vessels, rich in young, robust MSCs. These cells produce exosomes with high levels of growth factors, anti-inflammatory agents, and signaling molecules. It’s used because it’s ethically sourced abundant, and yields exosomes with potent regenerative properties.

How does XO DERM compare to bone marrow-derived exosomes?

Skin Health: XO DERM excel in promoting collagen synthesis and fibroblast activity, key for skin repair, due to their rich cargo (e.g., alpha-2-macroglobulin). Bone marrow exosomes also support healing but have lower yields and less consistent regenerative effects as donor age increases.

Inflammation: XO DERM show stronger anti-inflammatory effects, modulating immune responses via cytokines like IL-10, outperforming bone marrow exosomes, which can vary in potency with donor health.

Stemness: Wharton’s jelly MSCs are "younger" (from neonatal tissue), retaining higher stemness (ability to self-renew and differentiate) than bone marrow MSCs, which decline with age, making XO DERM more bioactive.

Why are XO DERM better than fat (adipose tissue)-derived exosomes?

Skin Health: While adipose-derived exosomes aid wound healing, XO DERM exosomes have higher levels of fibrinogen proteins and growth factors (e.g., TGF-α), giving them an edge in skin regeneration and scar reduction.

Inflammation: XO DERM more effectively reduce inflammation, thanks to their immune-modulating profile, whereas adipose exosomes may carry pro-inflammatory signals depending on the donor’s metabolic state (e.g., obesity).

Stemness: XO DERM MSCs are less exposed to environmental stressors than adipose MSCs, preserving greater stemness and producing exosomes with superior regenerative potential.

How do XO DERM stack up against bacteria-derived exosomes?

Skin Health: Bacterial exosomes (often called outer membrane vesicles) can trigger immune responses for infection control but lack the regenerative focus of XO DERM, which are optimized for tissue repair and collagen deposition.

Inflammation: Bacterial exosomes typically provoke inflammation to fight pathogens, while XO DERM suppress it, making them better for chronic conditions or skin rejuvenation.

Stemness: Bacteria don’t have stem cells, so their exosomes lack stemness-related benefits, unlike XO DERM, which inherit MSC-driven regenerative traits.

CosmedIQ™ Professional, the cutting-edge supplier redefining medical aesthetics. Delivering advanced, science-backed solutions, we empower clinicians with top-tier products—think exosomes, growth factors and beyond—sourced for maximum efficacy and safety.